The problem of suffering, as a fundamental challenge of human existence, is described in Arthur Schopenhauer’s philosophy as an inherent and inevitable consequence of the will to life, where endless desires cause frustration and pain, and liberation is attainable only through compassion, asceticism, and denial of the will. Influenced by Eastern ideas such as Buddhism, his pessimistic metaphysics sees suffering as the essence of existence and rejects Western optimism. In contrast, Abdullah Javadi Amoli, within the framework of Islamic transcendent wisdom, regards suffering as a non-essential phenomenon resulting from the imperfections of essences and the material world, not from divine being. For him, suffering serves as a means of spiritual education within the best order of creation, guiding humanity toward self-perfection and divine knowledge. Using an analytical-critical method, this article critiques Schopenhauer’s view through Javadi Amoli’s lens: ontologically, Schopenhauer’s blind will lacks theological depth and mistakes suffering as a positive force, while transcendental wisdom sees it as privation consistent with the unity of divine Act. Morally, Schopenhauer’s negation of will leads to passivity and nihilism, whereas Amoli’s perspective transforms suffering into a path of contentment and soul refinement. The study also contextualizes Schopenhauer’s selective use of Eastern traditions and his neglect of the constructive role of suffering. It concludes that Javadi Amoli’s approach not only critiques metaphysical pessimism but also offers a cross-cultural synthesis—reframing suffering as a catalyst for transcendence and as an architect of human existence.